Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp462 | Other diseases of bone and mineral metabolism | ECTS2013

Expression of RANKL/RANK/OPG in colon during experimental inflammatory bowel disease

Maric Ivana , Smoljan Ivana , Wensveen Tamara Turk , Lekic Andrica , Cvek Sanja Zoricic , Celic Tanja , Orlic Zeljka Crncevic , Bobinac Dragica

Introduction: The RANKL/RANK/OPG system has a key role in bone metabolism. Beyond its role in bone loss, its importance was also documented during inflammation which occurrs in inflammatory bowel disease (IBD). The aim of this study was to investigate the expression of the receptor activator of NF-κB ligand (RANKL) and its receptors RANK as well as its decoy receptor osteoprotegerin (OPG) in the colon during experimantal IBD and following BMP7 or corticosteroid therapy.</...